pentobarbital will lower the level or outcome of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; steer clear of use in clients who will be chronically working with a powerful CYP3A4 inducerWarning is warranted for people with rena